| Pair Name | Curcumin, Paclitaxel | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Expression | EGR1 | hsa1958 | |
| Down-regulation | Expression | EP300 | hsa2033 | |
| Down-regulation | Expression | MCL1 | hsa4170 | |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Up-regulation | Expression | SNIP1 | hsa79753 | |
| In Vitro Model | SK-OV-3 | Ovarian serous cystadenocarcinoma | Homo sapiens (Human) | CVCL_0532 |
| MDAH 2774 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0420 | |
| Result | Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity. Biochem Pharmacol. 2023 Jun;212:115581. doi: 10.1016/j.bcp.2023.115581. | Click |
